Use a pen

Hate the mouse!.  

I hate mice. I really do. If it weren't for web browsers, I'd likely never use a mouse. So what does it really mean to live a mouse-free lifestyle?

<snip loads of stuff about memorising keyboard shortcuts and macros for outlook>

 [via John Lam on Software]

Much much much (really) more effective is to use a something like a wacom tablet and pen. I can't draw, totally useless at graphics but using a pen has completely solved some RSI problems I was getting using a mouse.